Titrating Steroids on Exhaled Nitric Oxide in Children With Asthma: A Randomized, Controlled Trial
نویسنده
چکیده
METHODS. Children were randomly allocated to 1 of 2 groups stratified for baseline FeNO and dose of ICSs. In one group, ICS doses were determined by FeNO and symptoms according to an algorithm; in the other group, only symptoms influenced ICS dosing. The study duration was 12 months, with 5 visits at 3-month intervals. FeNO was measured at each visit, and the ICS dose was then adapted to FeNO and/or symptom scores that were recorded during the previous 2 weeks.
منابع مشابه
Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial.
RATIONALE Corticosteroids are the antiinflammatory treatment of choice in asthma. Treatment guidelines are mainly symptom-driven but symptoms are not closely related to airway inflammation. The fraction of nitric oxide in exhaled air (FENO) is a marker of airway inflammation in asthma. OBJECTIVE We evaluated whether titrating steroids on FENO improved asthma management in children. METHODS ...
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